Benedetti is an Italian surname. Notable people with the surname include:
Alessio Benedetti (born 1990), Italian footballer
Alessio Benedetti (footballer, born 1997), Italian professional footballer
Amedeo Benedetti (writer) (1954–2017), Italian scholar and writer
Amedeo Benedetti (footballer) (born 1991), Italian footballer
Ângelo Sampaio Benedetti, or simply Ângelo (born 1981), Brazilian footballer
Armando Benedetti (born 1967), Colombian politician
Arturo Benedetti Michelangeli (1920–1995), Italian pianist
Atilio Benedetti (born 1955), Argentine politician
Carolina Benedetti, Colombian mathematician and educator
Cesare Benedetti (1920–2002), Italian footballer and painter
Cesare Benedetti (cyclist) (born 1987), Italian cyclist
Enrico Benedetti (1940–1996), Italian ice hockey player
Fabrizio Benedetti, Italian neuroscientist
Franco Benedetti (1932–2009), Italian wrestler
Gastón Benedetti (born 2001), Argentine professional footballer
Georges Benedetti (1930–2018), French politician
Giacomo Benedetti (born 1999), Italian footballer
Giambattista Benedetti (1530–1590), Venetian mathematician
Giovanni Benedetti (1917–2017), Italian Roman Catholic bishop
Jonatan Benedetti (born 1997), Argentine professional footballer
Joseph B.