Polanco is a Spanish surname originating from the municipality of Polanco, Cantabria in Spain. Notable people with the surname include:
Alfonso Polanco, mayor of Palencia, Spain
Amelia Vega Polanco, Miss Universe 2003
Andrés López Polanco, painter active in 17th century in Valencia, Spain
Antonio Botín Polanco, Spanish writer from Santander, Cantabria
Carlos Enrique Polanco (born 1953), Peruvian painter
Dalilah Polanco (born 1971), Mexican actress
Dascha Polanco (born 1982), Dominican-American actress
Eduardo Saenz de Buruaga y Polanco, Spanish military general
Francisco Polanco, Spanish baroque painter of 17th century
Geovanny Polanco (born 1974), Dominican merengue singer
Gregory Polanco (born 1991), Dominican baseball player
Jenny Polanco (1958–2020), Dominican fashion designer
Jesús Polanco (1929–2007), Spanish businessman and founder of El Pais and Grupo PRISA.