Aiono is both a surname and a given name. Notable people with the name include:
Aiono Nonumalo Sofara, Samoan chief
Aiono Fanaafi Le Tagaloa (1932–2014), Samoan chief, historian, and writer
Alex Aiono (born 1996), American singer and YouTuber
James Aiono (born 1989), American football player
Uluomato'otua ("Ulu") Saulaulu Aiono (born 1954), Samoan-born New Zealand technology entrepreneur, civic leader, and philanthropist